Functional MRI has become a standard technique for exploring brain function, however this imaging modality is not a direct measure of neural activity. This course introduces the source of Blood Oxygenation Level Dependent (BOLD) contrast and the physiological mechanisms that drive the haemodynamic response to neural activity. The limitations and challenges of using blood as a surrogate for brain function are discussed, particularly in cohorts with differing cerebrovascular physiology. Potential solutions involving additional imaging modalities and complementary MRI contrast mechanisms may enable accurate understanding of the neuro-vascular processes underlying BOLD fMRI.
This abstract and the presentation materials are available to members only; a login is required.