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Abstract #7875

How Does Gd Enter the Brain, When the BBB is Intact?

Shinji Naganawa

Both linear-type and macrocyclic-type gadolinium based contrast agents (GBCAs) enter the CSF and perivascular spaces even without BBB disruption and renal insufficiency. Intrathecally injected GBCAs distribute in the brain parenchyma when the BBB is intact. The glymphatic pathway, the waste clearance system of the brain, is key to the Gd deposition issue.

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