The jarring clinical facts of NSF and the recent detection by MRI (an insensitive tool) of gadolinium in the dentate nucleus of the brain have brought GBCA stability and Gd deposition to attention. Numerous recent studies are contributing to a more thorough understanding of in vivo chemical deposition and pharmacokinetics and speciation of GBCA, and will soon stimulate studies to more deeply understand the toxicology of those species. This lecture will describe basic design and function principles and historical development of the GBCA emphasizing the links between chemical structure and gadolinium dissociation and deposition.
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