Cirrhosis and hepatocellular carcinoma (HCC) are major health problems world-wide and in the United States. It is estimated 10 to 20 million American people have non-alcoholic steatohepatitis (NASH), which can lead to cirrhosis. HCC is the second cause of cancer death world-wide, and the fastest growing cause of cancer death in the United States. MRI can provide information such as fat quantification, iron quantification in the liver, as well as liver stiffness estimation by MR elastography. Early and accurate diagnosis of HCC is critical for improved outcome of this deadly disease. Non-invasive diagnosis of chronic liver diseases and HCC are indispensable in hepatology practice. Current epidemiology of liver disease and how MRI can help liver patients’ management will be discussed.