Abstract #3432

Model-based reconstruction for IVIM and combined IVIM-DTI fitting: Initial experience

Susanne Rauh¹, Oliver Maier², Oliver Gurney-Champion³, Melissa Hooijmans³, Rudolf Stollberger^2,4, Aart Nederveen³, and Gustav Strijkers¹

¹Department of Biomedical Engineering and Physics, Amsterdam UMC, location AMC, Amsterdam, Netherlands, ²Institute of Medical Engineering, Graz University of Technology, Graz, Austria, ³Department of Radiology and Nuclear Medicine, Amsterdam UMC, location AMC, Amsterdam, Netherlands, ⁴BioTechMed-Graz, Graz, Austria

Model-based reconstruction can overcome many short-comings of IVIM and DTI by accelerating the acquisition, suppressing systematic errors from Rician noise and improving SNR. In this study we assess the feasibility of model-based reconstruction to obtain IVIM and combined IVIM-DTI parameter maps in the liver and kidneys in healthy volunteers. Results were compared to a conventional IVIM and IVIM-DTI least-squares fitting. Model-based reconstructions produced maps with less artifacts in liver and more details in the kidneys as compared to those from conventional fitting. Mean parameter values were similar for both methods.

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