Computational simulations and specifically random walks provide a unique opportunity to investigate how several confounding factors might affect the diffusion tensor cardiovascular magnetic resonance (DT-CMR) parameters. We investigate the effect of membrane permeability and diffusion time on the fractional anisotropy (FA) and mean diffusivity in a realistic histology-based 3D substrate considering two common sequence types. Comparing the results from permeable with that from impermeable membranes helps to considerably reduce FA towards levels expected from in-vivo DT-CMR. We further reveal that FA is unaffected by changes in diffusion times above 500ms. A similar, albeit weaker effect is observed regarding MD.
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