An increasing number of structural studies attempt identification of distinct structural regions based on their layer signature. Interestingly, water content quantitative contrast is little used in these attempts, despite being a fundamental contrast in MRI, based on the proton equilibrium magnetisation, and closely reflecting cell density on which modern cytoarchitectonic studies are based. In this contribution, we demonstrate the usefulness of water content contrast at 7T and propose it for layer-related studies and high-resolution brain anatomy.
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