As current therapeutic options for pancreatic cancer are mostly ineffective, developing diagnostic tools for early detection of precursor lesions (mainly pancreatic intraepithelial neoplasia – PanIN) could change the course of this disease. Here, we investigated Diffusion-MRI (dMRI) contrasts for this purpose, using transgenic mouse models. First, we performed ex vivo dMRI Microscopy at ultrahigh field with histological validation, defining the most sensitive contrasts. Then, we performed in vivo abdominal imaging, demonstrating their applicability in the non-invasive study of PanIN and pancreatic cancer. These findings provide new tools for researching PanIN and hold promise for a future translation to clinical practice.
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