Fibromyalgia (FM) is a disorder characterized by generalized pain. The acid saline-induced muscle (ASM) model is considered an acceptable animal model of FM with widespread chronic pain. Here, we investigated the impact of FM-like pain on neural communication, using the ASM model with non-invasive mouse resting state fMRI. We found that generalized pain reduces functional connectivity at the level of periaqueductal gray and retrosplenial cortex, two regions related to pain processing and FM. Moreover, we found a positive correlation between pain sensitivity measured by Von Frey test and the intensity of FC reduction at individual subject level.
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