Abstract #4443

Intravoxel incoherent motion (IVIM) and non-Gaussian diffusion MRI of the lactating breast

Mami Iima^1,2, Masako Kataoka¹, Rena Sakaguchi¹, Shotaro Kanao¹, Natsuko Onishi¹, Makiko Kawai¹, Katsutoshi Murata³, and Kaori Togashi¹

¹Department of Diagnostic Imaging and Nuclear Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan, ²Hakubi Center for Advanced Research, Kyoto University, Kyoto, Japan, ³Siemens Healthcare K.K., Tokyo, Japan

The effect of breastfeeding on IVIM and non-Gaussian diffusion MRI was investigated. ADC₀ and sADC values significantly decreased (P < 0.001 and P < 0.001) while K values significantly increased (P < 0.05) post-breastfeeding. fIVIM values significantly increased after breastfeeding (P < 0.01). No significant difference was found in D* values. There was significant heterogeneity in ADC₀ maps post-breastfeeding, both in retroareolar and segmental scores (P < 0.0001 and = 0.0001). IVIM and non-Gaussian diffusion parameters significantly changed between pre- and post-breastfeeding status, and care needs to be taken in interpreting DWI data in lactating breasts.

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