Abstract #4523

What is the Relationship between Vascular Disease Distribution in PAD and Exercise-Induced Hyperemia Pattern in Calf Muscle?

Christopher J Hanrahan¹, Jeff L Zhang¹, Gwenael Layec², Corey Hart², Michelle Mueller³, Daniel Kim¹, Kristi Carlston¹, Russell S Richardson², and Vivian S Lee¹

¹Radiology, Utah Center for Advanced Imaging Research (UCAIR), University of Utah School of Medicine, Salt Lake City, UT, United States, ²Internal Medicine, Division of Geriatrics, Utah Vascular Research Lab (UVRL), University of Utah School of Medicine, Salt Lake City, UT, United States, ³Surgery, University of Utah School of Medicine, Salt Lake City, UT, United States

Calf muscle perfusion by first-pass gadolinium MRI provides objective measures to help understand the relationship between vascular pathology and muscle dysfunction in peripheral arterial disease (PAD) patients. We compared perfusion in healthy and PAD subjects in exercise-recovery and, in the same PAD patients, related muscle perfusion pattern to hemodynamically significant vessel pathology found at MR arteriography. We found no relation between specific stenosis/occlusion and the expected muscle perfusion downstream, but calf vascular pathology significantly decreased perfusion in the superficial posterior compartment muscles compared to abdominopelvic/thigh vessel abnormality. Assessing muscle perfusion shows promise in assessing PAD disease severity and guiding treatment.

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