Alfredo Liubomir Lopez Kolkovsky1,2, Benjamin Marty1,2, Eric Giacomini1, and Pierre G Carlier1,2
1NMR Laboratory, Institut of Myology, Paris, France, 2NMR Laboratory, CEA/DSV/I2BM/MIRCen, Fontenay-aux-Roses, France
NMR allows to investigate multiple aspects of physiological
parameters like regional perfusion, blood and tissue oxygenation, intracellular
pH or high-energy phosphate metabolism. In the past, interleaved
multiparametric multinuclear dynamic NMR imaging and spectroscopy of skeletal
muscle was developed on prototype scanners. Here we evaluated an interleaved
pulse sequence combining the NMR acquisition of a 1H image and 31P
spectrum on a clinical system without any hardware modifications from the
customer. Having the possibility to run interleaved
multinuclear sequences on unmodified clinical systems will greatly facilitate
simultaneous measurements
of tissue perfusion, oxygen content and mitochondrial ATP production in
clinical research studies.
