Abstract #4495

Spotlight on gagCEST imaging in human menisci with MR-microimaging on ultra-high field 7T - a pilot study

Benedikt Hager^1,2,3, Sonja Walzer³, Matthew DiFranco⁴, Vladimir Juras^1,5, Vladimir Mlynarik^1,2, Markus Schreiner³, Martin Zalaudek¹, Stefan Domayer³, Esau Poblador Rodriguez¹, Andreas Berg⁴, Reinhard Windhager³, and Siegfried Trattnig^1,2

¹High Field MR Centre, Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria, ²Christian Doppler Laboratory for Clinical Molecular MR Imaging, Vienna, Austria, ³Department of Orthopaedic Surgery, Medical University of Vienna, Vienna, Austria, ⁴Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Vienna, Austria, ⁵Department of Imaging Methods, Institute of Measurement Science, Slovak Academy of Sciences, Bratislava, Slovakia

The purpose of this study was to examine whether gagCEST imaging reflects the histopathological changes concerning glycosaminoglycan in human meniscus in vitro. All MRI acquisitions were performed on 7T MRI with a microimaging system. Histological staining using safranin-O was performed for correlation to imaging findings. Qualitatively, the gagCEST map and the corresponding safranin-O image show the same relative regional intensity of glycosaminoglycans. In sum, gagCEST imaging in a 7T microimaging system allows a very detailed look into the glycosaminoglycan distribution in the human meniscus.

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