James MacKay1, Samantha Low1, Philip Murray1, Bahman Kasmai1, Glyn Johnson2, Simon Donell2,3, and Andoni Toms1,2
1Radiology, Norfolk & Norwich University Hospital, Norwich, United Kingdom, 2Norwich Medical School, University of East Anglia, Norwich, United Kingdom, 3Trauma & Orthopaedics, Norfolk & Norwich University Hospital, Norwich, United Kingdom
Subchondral bone (SB) plays an important role in
osteoarthritis (OA). Texture analysis (TA) is a method of quantifying changes
in SB and may be a useful OA biomarker. The optimum MR method to allow TA of SB
is unclear. We compared TA using two sequences which demonstrated promise in
depicting SB structure in three groups of participants: normal controls (n=10),
individuals with early OA (n=10) and individuals with advanced OA (n=10). TA
using a 2D T1-weighted spin echo sequence demonstrated more significant
differences in texture features between groups and improved classification
accuracy compared to a 3D gradient echo sequence.
