Abstract #4458

Feasibility of 50μm in vivo MR microscopy (μMRI) of mouse brain at 9.4 Tesla

Ferdinand Schweser^1,2, Claire M Modica^1,3, Nicola Bertolino¹, Paul Polak¹, Marilena Preda^1,2, and Robert Zivadinov^1,2

¹Buffalo Neuroimaging Analysis Center, Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ²MRI Molecular and Translational Research Center, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States, ³Neuroscience Program, Jacobs School of Medicine and Biomedical Sciences, The State University of New York at Buffalo, Buffalo, NY, United States

The technique of MR microscopy (μMRI) has evolved into an important tool for morphologic phenotyping and computational neuroanatomy research. However, due to the inherent challenges of mouse imaging, μMRI of mouse brain has so far mostly been limited to post mortem tissue, often relying on perfusion with a mixture of saline and a T1-shortening constant agent, which increases the MRI sampling efficiency.

In this work, we demonstrate the feasibility of in vivo μMRI of mouse brain at 9.4 Tesla with a resolution of 50μm using a cryogenic brain coil and an optimized imaging sequence.

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