Abstract #4451

Assessment of intrauterine growth restriction on pup rat brain by DTI and NODDI at 9.4T

Yohan van de Looij^1,2, Aline Rideau Batista Novais³, Olivier Baud³, Petra S Hüppi¹, and Stéphane V Sizonenko¹

¹Division of Child Growth & Development, Department of Pediatrics, University of Geneva, Geneva, Switzerland, ²Laboratory for Functional and Metabolic Imaging, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ³Inserm U1141 – DHU PROTECT, Robert Debré Hospital, Paris, France

Experimental studies of intrauterine growth restriction (IUGR) in the rat, induced by protein or caloric restriction, have shown to have extensive effects on brain development including white and grey matter structural changes [1]. The aim of this work was to establish offspring cerebral structural changes following low protein diet in rats during gestation by using DTI and NODDI. LPD microstructural consequences on pup rats at P10/P21 were characterized. At P10, structural changes were mainly found in the white matter whereas at P21 cortical structure was abnormally developed. DTI and NODDI give accurate probing of the cerebral impairment following IUGR.

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