1National Center of Magnetic Resonance in Wuhan, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences, Wuhan, China, People's Republic of
Permanent
bilateral common carotid arteries occlusion (2VO) rat model can induce
pathological changes in brain, do these changes induce MRI visible structural
changes? The enriched environment, an useful paradigm of increasing brain
structural plasticity, may have a structural effect on 2VO rat brain. In this
study the structural changes of 2VO rat brain with and without enriched
environment (EE) were studied by in vivo MRI. Our results showed that
sensorimotor cortex, dorsolateral striatum, cingulate cortex and dentate gyrus
represented significant atrophy after 2VO and EE effectively protected against
the gray matter atrophy.
