Abstract #4419

Absolute metabolite concentration of Creatine in the deep gray matter measured using short echo 1H-MRS predict long-term prognosis of neonatal hypoxic-ischemic encephalopathy as excellent as NAA concentration

Noriko Aida^1,2, Jun Shibasaki³, Moyoko Tomiyasu^1,2, Yuri Nishi^1,4, Naho Morisaki⁴, Takeo Fujiwara⁴, Katsuaki Toyoshima³, and Takayuki Obata²

¹Radiology, Kanagawa Children's Medical Center, Yokohama, Japan, ²Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan, ³Neonatology, Kanagawa Children's Medical Center, Yokohama, Japan, ⁴Social Medicine, National Research Institute for Child Health and Development, Tokyo, Japan

Absolute metabolite concentrations of N-acethylaspartate (NAA), Choline(Cho) and Creatine(Cr) in the deep gray matter of 44 near term neonates with hypoxic-ischemic encephalopathy (HIE), measured using PRESS method short echo 1H-MRS within 2 weeks after birth, showed excellent prognostic values (AUC; NAA: 0.98, Cho: 0.96, Cr: 0.99) with the adverse outcomes having significantly lower measurements compared to those with favorable outcomes, while Lactate was less efficient (AUC 0.74). Moreover NAA and Cr concentrations measured at 24-96 hours revealed perfect prognostic values (AUC 1.00). Early measurement of absolute Cr and NAA concentrations can be excellent biomarkers of infants suffered with neonatal HIE.

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