HARDI Acquisition in Neonates and Children using Modular Multiband Multi-shell Sequence
Vincent Kyu Lee1, Meredith Monsour2, Sudhir Pathak2, Vincent Schmithorst3, Catherine Fissell2, Ashok Panigrahy1,3, and Walt Schneider2
1Radiology, University of Pittsburgh, Pittsburgh, PA, United States, 2University of Pittsburgh, Pittsburgh, PA, United States, 3Children's Hospital of Pittsburgh, Pittsburgh, PA, United States
High
angular-resolution diffusion imaging (HARDI) is the best imaging technique to
distinguish crossing fibers and high turning angle neuronal tracts, which is critical
for identifying and characterizing the microstructural changes in neuro
pathology and traumatic brain injury.
Its main disadvantage has been the lengthy scan time needed to acquire
analyzable images – a challenge especially in children and neonates who do not
tolerate long scanning sessions. This study presents the preliminary fiber
tractography of healthy neonatal and pediatric subjects acquired using
multiband multi-shell HARDI sequence within a practicable scan time without
sacrificing image quality.
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