Abstract #4390

In vivo T1 mapping of the spinal cord using a reduced Field-of-View Inversion Recovery sequence (IR-ZOOM-EPI)

Marco Battiston¹, Torben Schneider², Claudia Angela Michela Gandini Wheeler-Kingshott^1,3, and Rebecca S Samson¹

¹NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Institute of Neurology, University College London, London, United Kingdom, ²Philips Healthcare, Guildford, United Kingdom, ³Brain Connectivity Center, C. Mondino National Neurological Institute, Pavia, Italy

The T₁ relaxation time is a fundamental quantitative Magnetic Resonance parameter widely used to characterize healthy and pathological tissue. However, investigation of quantitative T₁ in the human spinal cord has been limited to date. In this work, we propose a scan time efficient protocol in the spinal cord for Inversion Recovery T₁ mapping, which is considered the “gold-standard” method. The mean (± standard deviation) T₁ for white matter and grey matter in the cervical spinal cord were found to be respectively 1096 (±26) ms and 1153 (±24) ms.

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