Diffusion Corrected Aneurysm Wall Permeability as a Measure of Rupture Risk
Charles G Cantrell1, Parmede Vakil1,2, Sameer A Ansari3, and Timothy J Carroll1,3
1Biomedical Engineering, Northwestern, Chicago, IL, United States, 2College of Medicine, University of Illinois, Chicago, IL, United States, 3Radiology, Northwestern, Chicago, IL, United States
We report the first evidence of diffusion corrected DCE-MRI modeled contrast permeability in intracranial aneurysms and show the diffusion model more accurately represents physiology than previous methods. Permeability metrics, as measured in 23 patients, demonstrate a statistically significant trend with rupture risk as defined by anatomic imaging and clinical risk factors.
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