Peng Cao1, Angela Jakary1, Yan Li1, Sarah J. Nelson1, Doug Kelley2, and Peder E. Z. Larson1
1Department of Radiology, University of California at San Francisco, San Francisco, CA, United States, 2GE Healthcare, Waukesha, WI, United States
Mechanisms to create a
homogenous T2 contrast at 7T should be robust to both B0
and B1 inhomogeneities. This issue was addressed by applying a zero-degree
BIR-4 adiabatic pulse for T2 preparation. Simulation and in vivo experiments in mouse brain verified the robustness and contrast of the preparation
scheme at 7T. Application of this method was further demonstrated in a study of a patient with a brain
tumor. The adiabatic T2 weighting showed high intensity in the region
of the tumor, suggesting that the proposed method is likely to be useful in screening
and characterizing tumors.
