Abstract #4258

Beyond high resolution MPRAGE: In vivo T1-weighted imaging at 7T with 250 µm isotropic resolution using prospective motion correction

Falk Lüsebrink¹, Alessandro Sciarra¹, Hendrik Mattern¹, Renat Yakupov¹, and Oliver Speck^1,2,3,4

¹Biomedical Magnetic Resonance, Otto-von-Guericke University, Magdeburg, Germany, ²Leibniz Institute for Neurobiology, Magdeburg, Germany, ³Center for Behavioral Brain Sciences, Magdeburg, Germany, ⁴German Center for Neurodegenerative Disease, Magdeburg, Germany

Increasing the spatial resolution is of major importance to structural imaging as this may build bridges to optical microscopy and may lead to superior diagnostics and segmentations. Increasing the spatial resolution with sufficient SNR usually prolongs time of acquisition. This inevitably introduces more motion artifacts even with experienced subjects. However, this can be compensated by prospective motion correction. Increasing the resolution to a few hundred micrometers inherently reduces SNR such that reconstruction by sum of squares is not adequate anymore. Here we demonstrate our work on the acquisition and reconstruction of the currently highest resolution in vivo MPRAGE at 7T.

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