Chandan Aladahalli1, KS Shriram1, Dattesh Shanbhag1, Rakesh Mullick1, Reem Bedair2, Fiona Gilbert2, Andrew Patterson2, and Martin Graves2
Multi-parametric
longitudinal imaging is an important tool to monitor therapy response at
tumor locations. The key challenge in longitudinal data is the synchronization of
volumes across time points, as large variations are seen due to therapy response,
weight loss/gain, patient positioning, and surgery. We employ a group-wise registration
approach to synchronize the longitudinal volumes and compare/contrast it with a
more typical pair-wise registration approach. Group-wise approach results in consistent
registration across time-points as it does not require a reference image. The group-wise
non-rigid registration approach is demonstrated on longitudinal MRI data used
for assessing breast tumor therapy response.
