Abstract #4190

Altered Frontal Functional Networks in Adult Survivors of Pediatric Brain Tumors

Liya Wang^1,2, Hongbo Chen^1,3, Tricia Z King⁴, and Hui Mao¹

¹Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States, ²Radiology, Cancer Hospital Chinese Academy of Medical Sciences at Shenzhen, Shenzhen, China, People's Republic of, ³School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, China, People's Republic of, ⁴Psychology and Neuroscience Institute, Georgia State University, Atlanta, GA, United States

Pediatric brain tumors and associated treatment affect brain development and functional network. We investigated the functional connectivity (FC) of adult survivors of pediatric brain tumors using resting-state functional MRI and independent component analysis to better understand the neural mechanisms underlying long term cognitive outcomes of the survivors. It was found that survivors exhibited differences in the FC in executive control network, default mode network and salience network compared to demographically-matched controls with increased number of effective functional connectivities and increased FC strength in survivors compared the controls.

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