Abstract #4176

High grade intracranial gliomas exhibit widespread impaired cerebrovascular reactivity

Christiaan Hendrik Bas van Niftrik¹, Marco Piccirelli², Jan-Karl Burkhardt¹, Athina Pangalu², Antonio Valavanis², Michael Weller³, Oliver Bozinov¹, Luca Regli¹, and Jorn Fierstra¹

¹Department of Neurosurgery, University Hospital Zurich, Zurich, Switzerland, ²Department of Neuroradiology, University Hospital Zurich, Zurich, Switzerland, ³Department of Neurology, University Hospital Zurich, Zurich, Switzerland

Neurovascular uncoupling (false negative BOLD activation) can be found in patients with high grade gliomas. An underlying mechanism could be impaired cerebrovascular reactivity. We determined overall cerebrovascular reactivity (CVR) as well as the perifocal CVR and used a healthy control group. We applied an automated tumor masking with determination of CVR in 7 consecutive rings of 3 mm. We found an overall impaired CVR as well as significantly impaired intratumoral CVR and perifocal up to 12 mm. No such trend was found on the contralateral hemisphere, after flipping of the tumor mask.

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