Abstract #4128

Microstructural alterations detected by dMRI in KO mouse model showing schizophrenic like phenotype

Nicolas Kunz¹, Alexandre Bacq², Jocelin Grosse², Rolf Gruetter^1,3, and Carmen Sandi²

¹CIBM-AIT, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland, ²Laboratory of Behavioral Genetics, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland, ³Department of Radiology, University of Geneva and Lausanne, Geneva, Lausanne, Switzerland

Schizophrenia is a severe mental disorder that afflicts 1% of the world’s population. However, the cause of this disorder remains unknown. Increasing evidence points toward a neurodevelopmental mechanism, which implicates genes involved in neuronal proliferation, migration, or synapse formation. We investigate microstructural changes by ex-vivo diffusion MRI in PSA-KO mice brain. Trends of microstructural alterations were visible in a few fiber tracts such as ST, ST-post, AC and FX. These preliminary results suggest that altered plasticity during development of the PSA-KO mice, presenting schizophrenic like phenotype and altered sociability, creates long term effects and structural alterations depicted by dMRI.

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