2D Localised Correlated Spectroscopy (L-COSY): A potential tool for identifying biochemical changes in Multiple Sclerosis
Jameen ARM1, Scott Quadrelli2, Karen Ribbons3, Jeanette Lechner-Scott3, and Saadallah Ramadan4
1Imaging, HMRI, Newcastle, Australia, 2Imaging, TRI Brisbane, Brisbane, Australia, 3Neurology, John Hunter Hospital, Newcastle, Australia, 4Faculty of Health and Medicine, University of Newcastle, Newcastle, Australia
1H Magnetic Resonance
Spectroscopic techniques (1H-MRS) have been utilised to assess
inflammatory nature of both acute and chronic lesions as well as normal
appearing brain tissue to understand the neuro degenerative irreversible
component of multiple sclerosis (MS) from early stages1-3. However, due to
high spectral overlap in one-dimensional (1D) 1H-MRS, it has
been challenging to establish a standard specific spectral pattern in plaques
or normal appearing brain tissues. L-COSY might provide the needed spectral
dispersion
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