Evaluation of blood brain barrier permeability in Alzheimer’s disease with DCE-MRI
Rexford Newbould1, Brandon Whitcher2, Christopher Long3, Shaila Shabbir4, Paul Matthews5, Andrew Lockhart4, Craig Ritchie5, and Eugenii Ilan Rabiner1
1Imanova, London, United Kingdom, 2Klarismo, London, United Kingdom, 3MIT Sloan School of Management, Cambridge, MA, United States, 4GSK, Brentford, United Kingdom, 5Imperial College London, London, United Kingdom
DCE 3T MRI data acquired from 6 subjects with previous diagnoses
of AD, 2 subjects with vascular dementia, and 7 healthy controls group-matched
for age and gender. Radiofrequency
transmit (B1) field corrected Gd concentration values were calculated via dual-temporal
resolution dynamic T1 mapping during and over 45 minutes post rapid Gd infusion. The extended Tofts model was used to
determine the volume and rate transfer constants of BBB permeability in 11
regions of interest. No differences were
detected between groups, implying BBB leakage in AD is slower than detectable
in this experiment, or that BBB permeability in AD is moderated by an active
transport mechanism.
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