Marjolein Bulk1, Walid M. Abdelmoula1, Linda M. van der Graaf1, Mark A. van Buchem1, Pieter Voorn2, Jouke Dijkstra1, and Louise van der Weerd1,3
1Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Department of Anatomy and Neurosciences, VU University Medical Center, Amsterdam, Netherlands, 3Human Genetics, Leiden University Medical Center, Leiden, Netherlands
Investigating the histological correlates of MRI
contrasts in patients with Alzheimer’s disease (AD) will give more insight into
the pathological correlates of T2* and SWI. Using 7T MRI and histology of
post-mortem brain tissue we showed that the frontal cortex of AD patients has a
different imaging phenotype compared to non-demented controls, which spatially
correlates to changes in iron deposition and grey matter myelin organization
Most importantly, within the AD group the early-onset AD patients are
distinguishable on MRI from the late-onset AD patients, and these differences
are mirrored in the underlying pathology of these AD subtypes.
