Eva-Maria Ratai1,2, Kimberly A. Stephens1,2, Alison E. Goldblatt1,2, Jean-Philippe Coutu1,2, Ciprian Catana1,2, Diana Rosas2,3, and David Salat1,2
1Radiology, Massachusetts General Hospital, Boston, MA, United States, 2A. A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, 3Neurology, Massachusetts General Hospital, Boston, MA, United States
The
purpose of this study was to find associations between metabolites measures by
MRS and glucose metabolism using FDG PET and cerebral blood flow (CBF) measured
by ASL MRI in the assessment of Alzheimer’s Disease. Our study shows an association between increased
myo-inositol, a marker of glial inflammation, and hypo-metabolism measured by FDG as well hypo-perfusion measured by ASL. Liner
regression analysis revealed that creatine, a marker of altered energy
metabolism positively correlated with increased glucose uptake by FDG PET. Increased
levels of glutamate+glutamine (contributing to excitotoxicity) were related to decreased
metabolic activity by PET and decreased CBF.
