Joo-Yeon Kim1, Yeong-Jae Jeon1,2, Sang-Woo Kim1,2, and Hyeon-Man Baek1,2
1Bioimaging Reseach Team, Korea Basic Science Institute, Ochang, Korea, Republic of, 2Bio-Analytical Science, University of Science and Technology, Ochang, Korea, Republic of
The
aim of this study was to characterize hepatic lipid metabolites changes in
high-fat diet induced liver steatosis model using in vivo 1H-MRS. MR imaging
an single-voxel 1H-MRS was performed using a PRESS sequence at 9.4T. Significant increase in
lipid signals at 0.9, 1.3, 2.1, 2.3, 2.8, 4.1, 4.3, and 5.3 ppm was found in mice
with high-fat diet (p<0.001). TL, TUB, UI, and Cho
were increased with high-fat diet.Therefore, 1H-MRS is useful in detecting
and characterizing various hepatic lipid alterations at early phase in mouse
liver steatosis prior to development of fibrosis.
