Abstract #3987

The Influence of Varenicline on Repeated Nicotine-Induced Rats: In Vivo Proton Magnetic Resonance Spectroscopy at 9.4T

Song-I Lim^1,2, Kyu-Ho Song¹, Chi-Hyeon Yoo^1,2, Dong-Cheol Woo², and Bo-Young Choe¹

¹Department of Biomedical Engineering, and Research Institute of Biomedical Engineering, The Catholic University of Korea College of Medicine, Seoul, Korea, Republic of, ²Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of

Nicotine effects the activation of nicotinic acetylcholine receptors (nAChRs) in multiple areas of the brain. Varenicline is a partial agonist acting at the α4β2 nAChRs. The purpose of the study is to compare the in vivo effects of nicotine and varenicline that contribute to the reward system. The results show the tendency of increased Glu level in nicotine group. Moreover, GSH and NAA levels tended to decrease in the nicotine group. It satisfies that high resolution and short TE component adequately spilt the overlapped metabolite spectra and quantify the cerebral neurochemicals. We found that varenicline effectively inhibits the reward cycle.

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