Abstract #3982

In vivo comparison of quadrupole splitting of potassium resonance with dipole-dipole splitting of total creatine resonance in proton MR spectroscopy of human calf muscle

Manuela Barbara Rösler^1,2, Nicolas G.R. Behl¹, Nadia Benkhedah¹, Armin Michael Nagel^1,3, and Reiner Umathum¹

¹Medical Physics in Radiology, German Cancer Research Center, Heidelberg, Germany, ²Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, ³Diagnostic and Interventional Radiology, University Medical Center Ulm, Ulm, Germany

Theory predicts that the residual quadrupole interaction of spin-3/2 nuclei with electrical field gradients and the dipole-dipole interaction of coupled spin-1/2 nuclei depend similarly on the angle between the privileged direction and the static magnetic field. In this work, we compare the splitting of the ³⁹K resonance with the splitting of the total creatine resonance in ¹H MR spectroscopy in vivo at human calf muscle. We find similar behavior under variation of the angle between B₀ and tibia. Therefor we conclude that the potassium ions and creatine are located in an equivalent electromagnetic environments.

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