Abstract #3969

In vivo measurement of metabolic fluxes in mouse dorsal hippocampus using 1H-[13C] NMR spectroscopy at 14.1 Tesla

Antoine Cherix¹, Blanca Lizarbe¹, Hongxia Lei^2,3, and Rolf Gruetter^1,2,4

¹Laboratory for Functional and Metabolic Imaging (LIFMET), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ²Department of Radiology, University of Geneva, Geneva, Switzerland, ³Animal Imaging and Technology Core (AIT), Center for Biomedical Imaging (CIBM), Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland, ⁴Department of Radiology, University of Lausanne, Lausanne, Switzerland

¹H-[¹³C] MRS was applied in a mouse dorsal hippocampus to investigate brain metabolism in vivo. The measured fractional enrichments allowed to measure metabolic fluxes using a one compartment model of glucose metabolism. Results were similar to previous study using a 3 times bigger voxel. This study shows that metabolism of the mouse dorsal hippocampus, which is one of the most studied structures of the brain, can be assessed in vivo.

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