Lucian A. B. Purvis1, William T. Clarke1, Michael Pavlides1, Matthew D. Robson1, and Christopher T. Rodgers1
Phosphomonoesters (PME) and phosphodiesters (PDE) are emerging
biomarkers in cirrhosis and fatty liver disease. In this study, phosphorus (31P)
liver metabolite concentrations were quantified at 7T for 10 healthy volunteers
using a 28 minute, 3D UTE-CSI sequence and an endogenous 2.5mM ATP reference. The
inorganic phosphate concentration was 1.95 ± 0.18mM (1.25-2.43mM in the
literature). Summing individual ester peaks, the total PME and PDE
concentrations were 1.90 ± 0.29mM (cf. 1.98-3.89mM) and 4.31 ± 0.80mM (cf. 8.01-11.40mM).
We attribute this apparent reduction in PDE to a broadening of the underlying
phospholipid bilayer resonance and the increased spectral resolution at 7T.
