Charlie Yi Wang1, Yuchi Liu1, Shuying Huang1, Mark Alan Griswold1,2, and Xin Yu1,2
1Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, 2Radiology, Case Western Reserve University, Cleveland, OH, United States
We propose a novel 31P Creatine Kinase encoding Magnetic Resonance Fingerprinting method
(CK-MRF) to efficiently measure high energy phosphate metabolism through
creatine kinase (CK). Measurement reproducibility of CK rate constant (kf,CK)
using CK-MRF was compared with both conventional 31P saturation transfer
method, and Four Angle Saturation Transfer method in rat hind limb. CK-MRF measurement showed comparable or
superior reproducibility using 20 s experiment time compared to 160 s experiment
time of either comparison method.
Changes in kf,CK following Ischemia/Reperfusion (IR) were
also measured.
