Abstract #3942

Sensitivity Comparison of Ultrahigh-field Oxygen-17 MRS Imaging between 7T and 10.5T using a Human Head Size Phantom and Quadrature Surface Coil

Hannes Michel Wiesner¹, Xiao-Hong Zhu¹, Kamil Ugurbil¹, and Wei Chen¹

¹CMRR, Radiology, University of Minnesota Medical School, Minneapolis, MN, United States

In vivo ¹⁷O MRS imaging provides a valuable tool for quantitatively imaging the cerebral rate of oxygen metabolism, cerebral blood flow and oxygen extraction fraction from a brief inhalation of ¹⁷O-isotope labeled oxygen gas. In this study, we conducted a pilot test to examine the ¹⁷O sensitivity using the human head size water phantom in the world's first 10.5T whole-body human scanner at the CMRR, then compared it with that at 7T. We found approximately doubled ¹⁷O sensitivity at 10.5T after careful consideration signal and noise contributions at both fields.

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