Abstract #3922

Dietary Fat Content Modulates the Effect of Long-term Exercise on Intramyocellular and Intrahepatic Lipids but not on Weight or Insulin Sensitivity

Venkatesh Gopalan¹, Jadegoud Yaligar¹, Navin Michael², Lee Swee Shean¹, Suresh Anand Sadananthan², Anna Ulyanova¹, Bhanu Prakash KN¹, and S Sendhil Velan¹

¹Laboratory of Molecular Imaging, Singapore Bio-Imaging Consortium, BioMedical Sciences, Singapore, Singapore, ²Singapore Instiute for Clinical Sciences, Singapore, Singapore

The goal of this study was to investigate how dietary fat intake modulates the effect of long term exercise training on body weight, intrahepatic and intramyocellular lipids (IHL & IMCL), and effect on insulin sensitivity in an animal model of long-term exercise. Long term exercise was found to result in significant elevations in IMCL and IHL under low fat background diet, and significant reductions in IMCL and IHL under a high fat background diet, compared to sedentary diet-matched controls. Dietary fat content did not modulate the effect of exercise on insulin sensitivity.

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