Abstract #3895

Shortened Fatty Acid Chains in Cervical Cancer using 1H MRSI at 7T

Catalina S. Arteaga de Castro¹, Jacob P. Hoogendam², Alexander Raaijmakers¹, Irene M.L. van Kalleveen¹, Wouter B. Veldhuis³, Ronald P. Zweemer², Peter R. Luijten¹, and Dennis W.J. Klomp¹

¹Imaging Division, University Medical Center Utrecht, Utrecht, Netherlands, ²Gynaecological oncology, University Medical Center Utrecht, Utrecht, Netherlands, ³Radiology, University Medical Center Utrecht, Utrecht, Netherlands

The feasibility of MRSI at 7T to image fatty acid composition in cervical cancer patients was investigated . A relatively high 2.1 ppm fatty acid signal was only observed in tumor tissue. Tumor free cervix showed predominantly the 1.3 ppm lipids signal. Metabolic maps of the 2.1 ppm fatty acid showed heterogeneity within the tumor, which coincided with a hyper-intense area within the T2-weighted image, that may indicate local necrosis.

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