19F ZTE MR Imaging of 19F labeled calcium phosphate cement at 11.7T
Weiqiang Dou1, Simone Mastrogiacomo2, Olga Koshkina3, Andor Veltien1, Mangala Srinivas3, X. Frank Walboomers2, and Arend Heerschap1
1Radiology, Radboud University Medical Centre, Nijmegen, Netherlands, 2Biomaterials, Radboud University Medical Centre, Nijmegen, Netherlands, 3Tumor Immunology, Radboud University Medical Centre, Nijmegen, Netherlands
To enhance the MR
image contrast of calcium phosphate cement (CPC) to bone, it was tagged with a 19F
loaded nanoparticle as a contrast agent.
19F zero echo time (ZTE) MRI was applied for the first time for 19F
imaging of this CPC in bone at 11.7T. The T1 and T2*
relaxation times of the 19F nanoparticles were measured for optimal
settings of 19F ZTE MRI. We demonstrate overlaid 1H+19F
ZTE images of in vitro and ex vivo CPC/bone samples with hyperintense 19F
signals allowing a qualitative and quantitative evaluation of these samples.
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