Abstract #3866

Differences in perfusion fraction in different grade of prostate cancer assessed by DWI

Rossella Canese¹, Davide Fierro², Francesca Romana Giura², Gianmauro Palombelli¹, Elena Lucia Indino², Vincenzo Salvo², Carlo Catalano², and Valeria Panebianco²

¹Cell Biology and Neurosciences, Istituto Superiore di Sanita', Rome, Italy, ²Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Rome, Italy

To date, most clinical DW-MRI studies have employed a monoexponential model for data analysis, which produces the ADC parameter for assessing diffusion characteristics whose value correlate with Gleason scores in prostate cancer. The intravoxel incoherent motion (IVIM) model introduce a fast diffusing component in the signal due to perfusion effects, but the application of this method is not yet widespread included in clinical practice. This study was aimed at measuring the water diffusion in tissue separating and estimating the perfusion component by adopting a simple protocol easy to be implemented in clinical practice and evaluating its diagnostic performance

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