Abstract #3858

The effect of long diffusion time on the diffusion measurements of fibrotic human liver

Hui Zhang¹, Pairash Saiviroonporn², Ed X Wu^3,4, and Hua Guo¹

¹Center for Biomedical Imaging Research, Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing, China, People's Republic of, ²Department of Radiology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand, ³Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Hong Kong SAR, China, People's Republic of, ⁴Department of Electrical and Electronic Engineering, The University of Hong Kong, Hong Kong SAR, China, People's Republic of

To examine whether different diffusion times would yield different sensitivities in detecting the pathological alterations in tissue microstructure during liver fibrogenesis in human livers at 3 T. MRI including single-shot SE and simulated echo acquisition mode (STEAM) DWI EPI sequences were performed on 10 healthy volunteers and 19 liver fibrotic patients. One-way ANOVA with Turkey’s multiple comparison tests were employed to compare quantitative measurements between the volunteers and patients with different diffusion times. Results showed that diffusion measurements with higher diffusion times will be more sensitive as a biomarker to detect the pathological alterations in tissue microstructure in fibrotic patients.

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