Abstract #3819

Sample entropy (SampEn) differentiate patients with Major Depressive Disorder (MDD) from healthy controls and explores mechanism of MDD

Kai Wang¹, Yunwen Shao¹, Tongxin Chen¹, Chuangjian Cai¹, Yan Zhu², and Kui Ying^3,4

¹Department of Biomedical Engineering, Tsinghua University, Beijing, China, People's Republic of, ²Psychiatry Department, Yu Quan Hospital, Tsinghua University, Beijing, China, People's Republic of, ³Department of Engineering Physics, Tsinghua University, Beijing, China, People's Republic of, ⁴Key Laboratory of Particle and Radiation Imaging, Ministry of Education, Beijing, China, People's Republic of

Entropy indicates system irregularity. Sample Entropy (SampEn), an estimation of entropy in a relatively robust way, was used to differentiate patients with Major Depressive Disorder (MDD) from healthy controls and to explore the mechanism of MDD. In this work, we found five clusters with significantly different SampEn in MDD group from that of control group, located in left frontal lobe, left parietal lobe, left temporal lobe, cerebellum and occipital lobe respectively, and the overall accuracy obtained with linear support vector machine formed by SampEn of those regions was 86.7%(p=0.000).

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