Abstract #3799

Resting-State Functional Connectivity in Patients with Treatment-Resistant Depression

Jia Liu¹, Mingrui Xia², Qiyong Gong¹, and Yong He²

¹Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China, People's Republic of, ²State Key Laboratory of Cognitive Neuroscience and Learning& IDG/McGovern Institute for Brain Research, Beijing Normal University, Beijing, China, People's Republic of

We used a data-driven graph theoretical approach—whole-brain functional connectivity strength (FCS) mapping to investigate functional connectivity patterns in 24 patients with RDD, 40 patients with NDD, and 48 healthy comparison subjects. Our study indicated that when compared with HC, the alteration of FCS in NDD group was mainly located in the medial frontal gyrus while the alterations of RDD group were located in the non-medial frontal areas and NDD demonstrated lower FCS in the limbic regions which was not obvious in the RDD group. Meanwhile, lower FCS in the default mode network and visual recognition network was observed in the group with NDD when compared with the group with RDD.

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