Calibrated BOLD fMRI with an Optimized ASL-BOLD Dual-Acquisition Sequence
Maria A. Fernandez-Seara1, Zachary B. Rodgers2, Erin K. Englund2, Hee-Kwon Song2, John A. Detre3, Michael C. Langham2, and Felix W. Wehrli2
1Radiology, University of Navarra, Pamplona, Spain, 2Radiology, University of Pennsylvania, Philadelphia, PA, United States, 3Neurology, University of Pennsylvania, Philadelphia, PA, United States
Calibrated
fMRI techniques estimate task-induced changes in the cerebral metabolic rate of
oxygen (CMRO2) based on simultaneous measurements of cerebral blood
flow (CBF) and blood-oxygen-level-dependent (BOLD) signal changes evoked by
stimulation. To determine the calibration factor M (corresponding to the
maximum possible BOLD signal increase), BOLD signal and CBF are measured in
response to a gas breathing challenge (CO2, O2). Here we describe an ASL dual-acquisition sequence that combines a background-suppressed 3D
readout with 2D multi-slice EPI. In five subjects we found an average
gray matter M-value of 8.71±1.03 and fractional changes of CMRO2 of 12.5±5%
in response to a bilateral motor task.
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