Abstract #3709

Drug Distribution Kinetics in the Eye assessed by 1H-MRI and 19F-MRS

Christina R Haeuser¹, Alfred Ross¹, Markus von Kienlin¹, and Basil Künnecke¹

¹Roche Pharma Research and Early Development, F. Hoffmann-La Roche Ltd, Basel, Switzerland

Drug treatment of vision impairing diseases often involves intraocular drug injection into the vitreous humour, a highly viscous gel-like matter. Drug transport within the vitreous humour has remained rather elusive although transport processes are acknowledged to play a pivotal role for treatment efficacy and adverse effects in the target tissue. Here, we devised a potentially translational approach based on contrast-enhanced 1H-MRI and 19F-MRS to quantitatively ascertain intravitreal drug distribution kinetics at the macro-scale. We provided proof-of-concept for the small drug-like molecule trifluoroethanol in isolated porcine eyes.

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