MRI-Guided Thermosensitive Liposomal Drug Delivery for Cancer Therapy
Po-Wah So1, Maral Amrahli2, Michael Wright2, Miguel Centelles2, Wladyslaw Gedroyc3, Andrew Miller2, and Maya Thanou2
1Neuroimaging, King's College London, London, United Kingdom, 2Institute of Pharmaceutical Sciences, King's College London, London, United Kingdom, 3Experimental Medicine, Imperial College London, london, United Kingdom
We have designed and synthesised a novel liposome formulation, capable of releasing encapsulated drug on targeting/heating by focussed ultrasound (FUS) for cancer therapy and being visualised by MRI due to the incorporation of gadolinium chelates. We show the novel liposomes are targeted to tumours by FUS and MRI-visible in vivo and thus, suitable for theranostic applications in cancer.
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