Abstract #3698

Assessment of brain development in children with developmental delay using amide proton transfer weighted (APTw) MRI

Xiaolu Tang¹, Hong Zhang¹, Xuna Zhao^2,3, Jinyuan Zhou², and Yun Peng¹

¹Imaging Center, Beijing Children’s Hospital, Capital Medical University, Beijing, China, People's Republic of, ²Neurosection, Division of MR Research, Department of Radiology, Johns Hopkins University, Baltimore, MD, United States, ³Philips Healthcare, Beijing, China, People's Republic of

Amide proton transfer weighted (APTw) imaging is a novel molecular MRI technique that can noninvasively detect cytosolic endogenous mobile proteins and peptides in myelination process. However it is not well known to brain developments in children with developmental delay using APTw MRI. The aim of our work is to explore the brain development in children with developmental delay (DD) using APTw MRI. The final conclusion shows that APTw MRI is a promising technique to assess children with DD at a molecular level.

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