Quantification of macrophage recruitment in double and single hit head and neck cancer using fluorine-19 MRI
Aman Khurana1, Fanny Chapelin1, Hongyan Xu1, Partick McConville2, Quyen Nguyen3, and Eric Ahrens1
1Radiology, University of California, San Diego, San Diego, CA, United States, 2Molecular Imaging Inc. La Jolla, San Diego, CA, United States, 3Head & Neck Surgery, University of California, San Diego, San Diego, CA, United States
Head and neck carcinoma is a source of significant mortality worldwide, two prevalent subtypes include double and single hit tumors. We aimed to evaluate the role of infiltrating immune cells in worse clinical outcomes with double-hit tumor patients. A novel 19-Fluorine containing perfluorocarbon (PFC) emulsion was used to tag macrophages with high specificity and sensitivity and no background. The average number of 19F spins within the double hit tumors were approximately double compared to the single hit group. This quantifies the tumor associated macrophage burden of head and neck cancer using a PFC emulsion and proton/19F MRI.
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